With the outbreak of the Covid-19 pandemic, the past two and a half years have highlighted more than ever the need for a holistic policy approach when tackling phenomena such as zoonotic diseases (infectious diseases jumping from animals to humans). At the same time the way humanity is interacting with its environment needs to radically change to preserve not only our own but also our ecosystem’s health. If the status quo remains, future crises seem unavoidable. The project One Health for the Future explores the phenomena of zoonoses, antimicrobial resistance (AMR), and food safety and security threats, 3 phenomena that One Health aims at preventing and addressing.